Influence of the MIF polymorphism −173G C on Turkish postmenopausal women with osteoporosis
Yazarlar (8)
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
S. Tural Ondokuz Mayis Üniversitesi, Türkiye
S. Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
N. Kara Ondokuz Mayis Üniversitesi, Türkiye
G. Alayli Ondokuz Mayis Üniversitesi, Türkiye
M. K. Tumer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
O. Kuru Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Zeitschrift Fur Rheumatologie (Q4) | ||
| Dergi ISSN | 0340-1855 Dergi Bilgileri (2018) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 77 / 7 / 629–632 | DOI | 10.1007/s00393-017-0382-5 |
| Makale Linki | http://link.springer.com/10.1007/s00393-017-0382-5 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| BackgroundMIF, a proinflammatory cytokine, contributes to the pathogenesis of acute, chronic, and autoimmune inflammatory disorders and balances the suppressive effect of glucocorticoids on the immune system. There is an interaction between bone metabolism and the immune system via the production of cytokines. We aimed to analyze the relationship between the MIF gene −173G > C promoter polymorphism and osteoporosis.MethodsIn this case–control study performed in a university hospital, 286 samples (136 women with osteoporosis and 150 healthy age-matched controls) participated. The polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) assay was used to genotype the MIF gene polymorphism. The alleles and genotypes frequencies of patients and controls were compared using the χ2 test.ResultsThe genotype frequencies of MIF gene −173G > C polymorphism … |
| Anahtar Kelimeler |
| Genetic susceptibility | MIF | Osteoporosis | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 2 |
| Web of Science | 3 |
| Scopus | 6 |
| Google Scholar | 7 |