CLINICAL SIGNIFICANCE OF NCOA5 GENE RS2903908 POLYMORPHISM IN BEHCET'S DISEASE
Yazarlar (8)
Prof. Dr. Aydin Rustemoglu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Esra Erkol Inal
Süleyman Demirel University, Faculty Of Medicine, Türkiye
Süleyman Demirel University, Faculty Of Medicine, Türkiye
Ahmet Inanir Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Duygu Ekinci Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ulker Gul
Akdeniz Üniversitesi, Türkiye
Akdeniz Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Excli Journal | ||
| Dergi ISSN | 1611-2156 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 16 / 1 / 609–617 | DOI | 10.17179/excli2017-189 |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Behçet’s disease (BD) is an autoimmune multisystemic disease. The precise etiology of BD is not fully understood; however, it is thought that interactions between genetic and environmental factors play an essential role in its pathogenesis. The nuclear receptor coactivator-5 (NCOA5) gene encodes a coregulator for nuclear receptor subfamily 1 group D member 2 (NR1D2) and estrogen receptor 1 and 2 (ESR1 and ESR2). Also, the NCOA5 gene insufficiency leads to an elevated expression of IL-6, and increased levels of IL-6 were found to be related to the pathogenesis of BD. In this study, we aimed to clarify the impact of the NCOA5 rs2903908 polymorphism on susceptibility and clinical findings of BD. This study included 671 participants (300 BD patients and 371 healthy controls). The analyses of NCOA5 rs2903908 polymorphism was performed by using the TaqMan allelic discrimination assay. The frequency of TT genotype of the NCOA5 rs2903908 polymorphism was found significantly higher in BD patients compared to those in healthy controls (p=0.016, OR=1.46, 95% CI=1.08-1.99). Also, the frequencies of CT genotype was observed significantly higher in BD patients with genital ulceration and uveitis than without genital ulceration and uveitis (p=0.002 and p=0.005, respectively). The most significant association was found between C allele frequencies of BD patients with and without uveitis (p=0.0001). Our study represents for the first time that the NCOA5 rs2903908 polymorphism seemed to be linked to BD susceptibility and clinical findings. |
| Anahtar Kelimeler |
| Behçet’s disease | NCOA5 | rs2903908 | Uveitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |