Analysis of Manganese Superoxide Dismutase and Glutathione Peroxidase 1 Gene Polymorphisms in Vitiligo
 
Yazarlar (7)
Havva Yıldız Seçkin
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Göknur Kalkan Ankara Yildirim Beyazit University, Türkiye
İlknur Bütün
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ali Akbaş Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yalçın Baş
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İsmail Benli
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Biochemical Genetics
Dergi ISSN 0006-2928 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 08-2016
Cilt / Sayı / Sayfa 54 / 4 / 438–447 DOI 10.1007/s10528-016-9730-4
Makale Linki http://link.springer.com/10.1007/s10528-016-9730-4
UAK Araştırma Alanları
Tıbbi Biyoloji
Özet
Vitiligo is a hereditary/acquired progressive pigmentation disorder characterized by discoloration of skin as a result of melanocyte dysfunction. Recent studies have proposed that oxidant/antioxidant status plays an important role in vitiligo pathogenesis because of the toxic effects on melanocytes. In this study, we aimed to investigate possible associations of MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms with vitiligo with in Turkish population. The study group consists of 57 patients with vitiligo and 69 healthy controls. Genotyping is performed to identify MnSOD Ala-9Val and GPx1 Pro198Leu polymorphisms. The method used for genotyping was based on the PCR amplification and detection of polymorphisms by hybridization probes labeled with fluorescent dyes. Both the genotype and allele frequencies of MnSOD Ala-9Val (p = 0.817 and p = 0.553, respectively) and GPx1 Pro198Leu polymorphisms (p = 0 …
Anahtar Kelimeler
GPx1 | MnSOD | Polymorphism | Vitiligo
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 2
Scopus 2
Google Scholar 3
Analysis of Manganese Superoxide Dismutase and Glutathione Peroxidase 1 Gene Polymorphisms in Vitiligo

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