Association of Genetic Polymorphisms in TNF and MIF Gene with the Risk of Primary Dysmenorrhea
Yazarlar (6)
Hatice Yilmaz Dogru Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ilhan Bahri Delibas Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Cigdem Kunt Isguder Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biochemical Genetics (Q4) | ||
| Dergi ISSN | 0006-2928 Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2016 |
| Cilt / Sayı / Sayfa | 54 / 4 / 457–466 | DOI | 10.1007/s10528-016-9732-2 |
| Makale Linki | http://link.springer.com/10.1007/s10528-016-9732-2 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Primary dysmenorrhea, which affects 90 % of adolescent girls and more than 50 % of menstruating women worldwide, is characterized by recurrent pain during menses in the absence of a detectable organic disease. The aim of this study is to assess the association between MIF −173 and TNF −308 genetic polymorphisms and the clinical features of primary dysmenorrhea. The study population comprised 154 unrelated female patients with clinical diagnosis of dysmenorrhea, and a total of 144 control subjects were recruited consecutively. The MIF −173G > C promoter polymorphism (rs755622) and TNF gene −308G > A (rs1800629) polymorphism were analyzed by polymerase chain reaction-based restriction fragment length polymorphism assay. Two fragments (268 and 97 bp) were seen when the G allele was present at position –173, and three fragments (206, 97, and 62 bp) were observed when the C allele … |
| Anahtar Kelimeler |
| Dysmenorrhea | Macrophage migration inhibitory factors | Pain | Single nucleotide polymorphism | Tumor necrosis factor-alpha |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 9 |
| Web of Science | 15 |
| Scopus | 15 |
| Google Scholar | 25 |