The importance of MTHFR C677T A1298C combined polymorphisms in pulmonary embolism in Turkish population
Yazarlar (6)
Nursah Basol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Asli Yasemen Savas Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ilker Kaya Tokat State Hospital, Türkiye
Kayhan Karakus Tokat State Hospital, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medicina Lithuania (Q3) | ||
| Dergi ISSN | 1010-660X Dergi Bilgileri (2016) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 52 / 1 / 35–40 | DOI | 10.1016/j.medici.2016.01.003 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S1010660X16000057 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background and objectivePulmonary embolism (PE) is an important cardiovascular emergency with high mortality. There are still problems related to the diagnosis of PE and genetic research may play a key role on diagnosis as well as determining risk stratification. In the present study, the aim was to evaluate MTHFR C677T and A1298C polymorphisms that play a role on folate metabolism in PE patients.Materials and methodsA total of 118 PE patients and 126 controls were enrolled in the current study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses for the MTHFR C677T and A1298C polymorphisms.ResultsThere was no association between clinical and demographic characteristics of PE patients and both MTHFR C677T and A1298C polymorphisms. Allele frequencies showed a significant difference between patients and controls. T allele frequency was significantly … |
| Anahtar Kelimeler |
| A 1298C | C677T | MTHFR | Polymorphism | Pulmonary embolism |
Science Direct
The importance of MTHFR C677T A1298C combined polymorphisms in pulmonary embolism in Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 3 |
| Web of Science | 9 |
| Scopus | 10 |
| Google Scholar | 19 |