Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer
Yazarlar (6)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nurten Kara
Ondokuz Mayis University, Medical School, Türkiye
Ondokuz Mayis University, Medical School, Türkiye
Ali N. Ulusoy
Ondokuz Mayis University, Medical School, Türkiye
Ondokuz Mayis University, Medical School, Türkiye
Cihangir Ozaslan
Ankara Oncology Education And Research Hospital, Türkiye
Ankara Oncology Education And Research Hospital, Türkiye
Prof. Dr. Sengul Tural Ondokuz Mayis University, Medical School, Türkiye
Prof. Dr. Ismail Okan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Oncology Research and Treatment | ||
| Dergi ISSN | 2296-5270 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2015 |
| Cilt / Sayı / Sayfa | 38 / 9 / 418–422 | DOI | 10.1159/000438940 |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Polymorphisms of estrogen synthesis-and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP-2548G>A (rs7799039) gene polymorphisms and breast cancer. Material and Methods: 199 breast cancer patients and 197 healthy controls were included in the study. The CYP17A1 and LEP gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism analysis. Results: No statistically significant association was found between these polymorphisms and breast cancer risk among a Turkish population. However, stratified analysis of these polymorphisms in relation to different clinicopathological characteristics of breast cancer revealed an association between breast cancer diagnosis and the CYP17A1 T27C polymorphism (p = 0.024). Conclusion: Our study suggests no strong association between the CYP17A1 T27C and LEP-2548G>A polymorphisms and the incidence of breast cancer in Turkish women. The potential association between CYP17A1 T27C and the type of breast cancer deserves further consideration. |
| Anahtar Kelimeler |
| Breast cancer | CYP17A1 | Genetic susceptibility | Leptin | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |