MTHFR and IL-4 Gene Polymorphisms Are Not Associated with Primary Dysmenorrhea in Young Adults
Yazarlar (8)
Prof. Dr. Asker Zeki ÖZSOY Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Bulent Cakmak Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Mehmet Can Nacar Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Ali Cetin Cumhuriyet Üniversitesi, Türkiye
Fazli Demirturk Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hatice Yilmaz Dogru
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Human Genetics | ||
| Dergi ISSN | 0972-3757 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2015 |
| Cilt / Sayı / Sayfa | 15 / 2 / 73–79 | DOI | 10.1080/09723757.2015.11886255 |
| Makale Linki | https://avesis.cumhuriyet.edu.tr/yayin/9749f962-a97a-4c8f-84e2-b7aa6feca6e7/mthfr-and-il-4-gene-polymorphisms-are-not-associated-with-primary-dysmenorrhea-in-young-adults | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Primary dysmenorrhea is one of the most common conditions among young adult females. The purpose of the present study was to investigate possible associations between the functional MTHFR gene C677T and IL-4 gene intron 3 VNTR polymorphisms with primary dysmenorrhea susceptibility in a Turkish population. One hundred and fifty-nine unrelated young women with primary dysmenorrhea and 135 unrelated healthy age-matched controls. Genomic DNA were isolated and MTHFR gene C677T polymorphism genotyped using polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) assay and IL-4 gene intron 3 VNTR polymorphism genotyped by using PCR with specific primers. The distribution of genotype and allele frequencies was not statistically different between the primary dysmenorrhea patients and healthy controls (p>0.05). According to the findings of first study of … |
| Anahtar Kelimeler |
| Dysmenorrhea | Genetic variant | IL4 gene | MTHFR gene | Population genetics |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |