Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis
Yazarlar (7)
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ahmet Inanir Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Akin Tekcan Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Ercan Tural Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Gokhan Tuna Ozturk Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Gorkem Kismali Ankara Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2014 |
| Cilt / Sayı / Sayfa | 537 / 1 / 6–9 | DOI | 10.1016/j.gene.2013.12.060 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S037811191400002X | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| ObjectiveInterleukin-4 (IL-4) is a strong chondroprotective cytokine and polymorphisms within this gene may be a risk factor for osteoarthritis (OA). We aimed to investigate genotype and allele frequencies of IL-4 gene intron 3 variable number of tandem repeats (VNTR) polymorphism in patients with knee OA in a Turkish population.MethodsThe study included 202 patients with knee OA and 180 healthy controls. Genomic DNA was isolated and IL-4 gene 70 bp VNTR polymorphism determined by using polymerase chain reaction (PCR) with specific primers followed by restriction fragment length polymorphism (RFLP) analysis.ResultsOur result show that there was statistically significant difference between knee OA patients and control group with respect to IL-4 genotype distribution and allele frequencies (p = 0.000, OR: 0.20, 95% CI: 0.10–0.41, OR: 0.22, 95% CI: 0.12–0.42, respectively).ConclusionsOur findings … |
| Anahtar Kelimeler |
| Interleukin-4 (IL-4) | Knee osteoarthritis | Polymorphism |
Science Direct
Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 20 |
| Scopus | 23 |
| Google Scholar | 38 |