The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy
Yazarlar (4)
Ahmet Inanir Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nursah Basol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2013 |
| Cilt / Sayı / Sayfa | 530 / 2 / 253–256 | DOI | 10.1016/j.gene.2013.07.051 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0378111913009591 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| BackgroundDiabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus (DM) due to decreasing quality of life. In the present study, it is aimed to evaluate angiotensin-converting enzyme (ACE) Gene I/D polymorphism in Turkish population.Materials and methodsTwo hundred and thirty-five DPN patients and two hundred and eighty-one controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses for the ACE gene I/D polymorphism.ResultsBaseline characteristics of the DPN patients according to ACE genotypes were similar, except for history of hypertension. The frequency of II genotype was significantly higher in patients with positive history of hypertension than the patients with negative history of hypertension (p = 0.013). DD genotype of I/D polymorphism was found to be a susceptibility factor for DPN in … |
| Anahtar Kelimeler |
| Angiotensin-converting enzyme | Bp | Diabetic peripheral neuropathy | Gene Polymorphism |
Science Direct
The importance of association between angiotensin-converting enzyme (ACE) Gene I/D polymorphism and diabetic peripheral neuropathy
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 22 |
| Scopus | 21 |
| Google Scholar | 32 |