High Association of IL-4 Gene Intron 3 VNTR Polymorphism with Diabetic Peripheral Neuropathy
Yazarlar (5)
Nursah Basol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ahmet Inanir Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Suheyla Uzun Kaya
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Neuroscience | ||
| Dergi ISSN | 0895-8696 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2013 |
| Cilt / Sayı / Sayfa | 51 / 2 / 437–441 | DOI | 10.1007/s12031-013-0048-y |
| Makale Linki | https://link.springer.com/article/10.1007/s12031-013-0048-y | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
|
||
| Özet |
| Diabetic peripheral neuropathy (DPN) is a common disease. It is one of the late complications of diabetes mellitus. DPN can lower the quality of life by causing severe painful clinic symptoms. The aim of this study is to evaluate interleukin (IL)-4 gene variable number of tandem repeat (VNTR) polymorphism on DPN in Turkish population. Two hundred and twenty-seven DPN patients and 241 controls were enrolled in this study. Genomic DNA was isolated and genotyped using polymerase chain reaction analyses for the IL-4 gene intron 3 VNTR polymorphism. The distribution of genotype frequencies of IL-4 gene intron 3 VNTR polymorphism was statistically different between DPN patients and control group (p = 0.001). The frequency of P1 and P2 alleles was statistically different between DPN patients and control group (p = 0.00009). The results of this study suggested that intron 3 VNTR polymorphism of the IL … |
| Anahtar Kelimeler |
| Diabetic peripheral neuropathy | Gene polymorphism | Interleukin 4 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 19 |
| Scopus | 18 |
| Google Scholar | 31 |