The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population
Yazarlar (7)
Prof. Dr. Goknur Kalkan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yalcin Bas
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Zennure Takci
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Pinar Ozuguz
Afyon Kocatepe Üniversitesi, Türkiye
Afyon Kocatepe Üniversitesi, Türkiye
Omer Ates
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi ISSN | 0378-1119 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2013 |
| Cilt / Sayı / Sayfa | 527 / 2 / 565–569 | DOI | 10.1016/j.gene.2013.05.086 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0378111913007737 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| ObjectiveAlopecia areata (AA) is hypothesized to be an organ-specific autoimmune disease of hair follicles mediated by T cells. As immunological and genetic factors have been implicated in the pathogenesis of AA, the purpose of the present study was to investigate possible associations between the functional Interleukin (IL)-4 gene intron 3 VNTR polymorphism and AA susceptibility and disease progression in Turkish population.MethodsThe study group consisted of 116 unrelated patients with AA and 125 unrelated healthy controls. Genomic DNA was isolated and IL-4 gene 70 bp VNTR polymorphism determined by using polymerase chain reaction (PCR) with specific primers.ResultsNo association was observed between AA patients and controls according to genotype distribution (p = 0.051). The allele distribution of IL-4 gene intron 3 VNTR polymorphism was statistically different between AA patients and … |
| Anahtar Kelimeler |
| Alopecia | Alopecia areata | Genetic skin disorders | IL-4 | Polymorphism |
Science Direct
The association between Interleukin (IL)-4 gene intron 3 VNTR polymorphism and alopecia areata (AA) in Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 37 |
| Scopus | 43 |
| Google Scholar | 60 |