High association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with recurrent aphthous stomatitis
Yazarlar (4)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Goknur Kalkan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Saime Sezer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Archives of Dermatological Research (Q2) | ||
| Dergi ISSN | 0340-3696 Dergi Bilgileri (2013) | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2013 |
| Cilt / Sayı / Sayfa | 305 / 6 / 513–517 | DOI | 10.1007/s00403-013-1333-x |
| Makale Linki | https://link.springer.com/article/10.1007/s00403-013-1333-x | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Recurrent aphthous stomatitis (RAS) is a common ulcerative disease of the oral mucosa. Oral ulcers are also the most common feature of Behçet’s disease (BD). Association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with BD has been reported in Turkish population. The aim of the present study was to investigate the possible association between ACE gene I/D polymorphism and RAS, and evaluate if there was an association with clinical features in a relatively large cohort of Turkish patients. The study included 198 patients affected by RAS and 214 healthy controls. ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction with I and D allele-specific primers. The genotype and allele frequencies of I/D polymorphism showed statistically significant differences between RAS patients and controls (p < 0.0001 and p < 0.0001, respectively). After … |
| Anahtar Kelimeler |
| Angiotensin-converting enzyme (ACE) | Genetic susceptibility | Insertion/deletion polymorphism | Recurrent aphthous stomatitis (RAS) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 8 |
| Web of Science | 10 |
| Scopus | 9 |