Association between 1603C>T polymorphism of DBH gene and bipolar disorder in a Turkish population
Yazarlar (5)
Omer Ates Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Feryal Cam Celikel Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Serap Erdogan Taycan Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Saime Sezer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene (Q3) | ||
| Dergi ISSN | 0378-1119 Dergi Bilgileri (2013) | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2013 |
| Cilt / Sayı / Sayfa | 519 / 2 / 356–359 | DOI | 10.1016/j.gene.2013.01.031 |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-84875613964&partnerID=MN8TOARS | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objectives: Dopamine-β-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Bipolar disorder is a major psychiatric disorder. The present study was designed to explore the associations of polymorphisms of DBH gene in Turkish patients with bipolar disorder. Methods: -. 1021C>T (rs1611115) polymorphism in promoter region, 444G>A (rs1108580) polymorphism in exon 2 and 1603C>T (rs6271; C535R) polymorphism in exon11 of DBH gene were analyzed in 106 patients with bipolar disorder and 106 healthy subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism and bipolar disease (p = 0.0012 and p = 0.034, respectively). There was no association observed between the genotype and allelic frequencies for -. 1021C>T and 444G>A polymorphisms and bipolar disorder. Conclusions: Our data suggests that the 1603C>T polymorphism of the DBH gene is associated with susceptibility to bipolar disorder in a Turkish population. © 2013 Elsevier B.V. |
| Anahtar Kelimeler |
| Association study | Bipolar disorder | DBH | Genetic susceptibility | Polymorphism |
Science Direct
Association between 1603C>T polymorphism of DBH gene and bipolar disorder in a Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Scopus | 19 |