Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population
Yazarlar (4)
Omer Ates
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Saime Sezer
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of the Neurological Sciences | ||
| Dergi ISSN | 0022-510X Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2013 |
| Cilt / Sayı / Sayfa | 326 / 1 / 64–67 | DOI | 10.1016/j.jns.2013.01.013 |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
|
||
| Özet |
| Migraine, a very common headache disorder, is regarded as a polygenic disease and serotonergic pathways appear to play a major role in its pathogenesis. The present study was designed to explore the associations of polymorphisms of 5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) and 5-hydroxytryptamine receptor 1B (5-HT1B) genes in Turkish migraine patients. 5-HT1A C-1019G (rs6295) promoter and 5-HT1B G861C (rs6296) exon polymorphisms in 203 migraine patients and 202 healthy subjects were analyzed by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Allele and genotype frequencies were not significantly different between migraine patients and healthy subjects for both the 5-HT1A C-1019G promoter and 5-HT1B G861C exon polymorphisms. Our data do not support the hypothesis that 5-HT1A C-1019G and 5-HT1B G861C polymorphisms have effects on migraine. © 2012 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| 5-HT1A | 5-HT1B | Genetic susceptibility | Migraine | Polymorphism |
Science Direct
Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |