DD genotype of ACE gene I/D polymorphism is associated with Behcet disease in a Turkish population
Yazarlar (9)
Serbulent Yigit Tokat Gaziosmapasa University, Türkiye
Sengul Tural Ondokuz Mayis Üniversitesi, Türkiye
Aydin Rustemoglu Tokat Gaziosmapasa University, Türkiye
Ahmet Inanir Tokat Gaziosmapasa University, Türkiye
Ulker Gul Ankara Numune Education And Research Hospital, Türkiye
Goknur Kalkan Tokat Gaziosmapasa University, Türkiye
Songul Akkanet Tokat Gaziosmapasa University, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates Tokat Gaziosmapasa University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Biology Reports (Q3) | ||
| Dergi ISSN | 0301-4851 Dergi Bilgileri (2013) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Cilt / Sayı / Sayfa | 40 / 1 / 365–368 | DOI | 10.1007/s11033-012-2069-y |
| Makale Linki | https://link.springer.com/article/10.1007/s11033-012-2069-y | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Behcet’s disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD … |
| Anahtar Kelimeler |
| Angiotensin-converting enzyme | Behcet's disease | Polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Scopus | 15 |