Association between the methylene tetrahydrofolate reductase gene C677T mutation and colchicine unresponsiveness in Behcet's disease
Yazarlar (9)
Doç. Dr. Nevin KARAKUŞ Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Goknur Kalkan
Prof. Dr. Aydin Rustemoglu Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ahmet Inanir
Ulker Gul
Ankara Numune Education And Research Hospital, Türkiye
Ankara Numune Education And Research Hospital, Türkiye
Gunseli Sefika Pancar
Tokat State Hospital, Türkiye
Tokat State Hospital, Türkiye
Songul Akkanet Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Omer Ates
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Vision | ||
| Dergi ISSN | 1090-0535 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2012 |
| Cilt / Sayı / Sayfa | 18 / 1 / 1696–1700 | DOI | – |
| Makale Linki | https://pmc.ncbi.nlm.nih.gov/articles/PMC3388981/ | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Purpose Behcet’s disease (BD) is a multisystemic immunoinflammatory disorder characterized by mucocutaneous, ocular, vascular, and central nervous system manifestations. The common methylene tetrahydrofolate reductase (MTHFR) gene C677T mutation is a known risk factor for thrombosis. The aim of this study was to investigate the MTHFR gene C677 mutation in patients with BD and evaluate if there was an association with clinical features, especially thrombosis, in a relatively large cohort of patients with BD. Methods The study included 318 patients with BD and 207 healthy controls. Genomic DNA was isolated and genotyped using PCR-based restriction fragment length polymorphism assay for the MTHFR gene C677T mutation. Results The genotype and allele frequencies of the C677T mutation showed a statistically significant difference between BD patients and controls (p=0.003 and p=0.001 … |
| Anahtar Kelimeler |
