Tumor Necrosis Factor Alpha and Beta and Interferon Gamma Gene Polymorphisms in Turkish Breast Cancer Patients
Yazarlar (5)
Doç. Dr. Nevin KARAKUŞ Ondokuz Mayis Üniversitesi, Türkiye
Nurten Kara Ondokuz Mayis Üniversitesi, Türkiye
Ali Naki Ulusoy Ondokuz Mayis Üniversitesi, Türkiye
Cihangir Ozaslan Research Hospital, Türkiye
Yuksel Bek Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | DNA and Cell Biology (Q3) | ||
| Dergi ISSN | 1044-5498 Dergi Bilgileri (2011) | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2011 |
| Cilt / Sayı / Sayfa | 30 / 6 / 371–377 | DOI | 10.1089/dna.2010.1113 |
| Makale Linki | https://journals.sagepub.com/doi/abs/10.1089/dna.2010.1113 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Cytokine genes are important for researching cancer predisposition to cancers that elicit anti-tumor immune response. In this study, we investigated the association between breast cancer and tumor necrosis factor alpha (TNF-α) −308 (G>A), TNF-β +252 (A>G), and interferon gamma (IFN-γ) +874 (T>A) gene polymorphisms in a Turkish population. This study involved 204 female breast cancer patients and 204 healthy female controls. Genomic DNA was extracted from EDTA-preserved peripheral venous blood of patients and controls by a salting-out method and analyzed by polymerase chain reaction, allele-specific oligonucleotide polymerase chain reaction, and restriction fragment length polymorphism. TNF-α −308 genotype was found to have no effect on breast cancer susceptibility. However, there were statistically significant differences between the genotype frequencies of patients and controls for TNF-β … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Yöksis | 5 |
| Web of Science | 18 |
| Scopus | 23 |