Lack of association between prohibitin 3′ untranslated region C→T polymorphism and breast cancer in a Turkish population
Yazarlar (3)
Doç. Dr. Nevin KARAKUŞ Ondokuz Mayis Üniversitesi, Türkiye
Nurten Kara Ondokuz Mayis Üniversitesi, Türkiye
Ali Naki Ulusoy Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | DNA and Cell Biology (Q3) | ||
| Dergi ISSN | 1044-5498 Dergi Bilgileri (2008) | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2008 |
| Cilt / Sayı / Sayfa | 27 / 8 / 449–452 | DOI | 10.1089/dna.2007.0724 |
| Makale Linki | https://journals.sagepub.com/doi/abs/10.1089/dna.2007.0724 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| The 3′ untranslated region (3′UTR) of the prohibitin gene has a positive effect on arresting cell proliferation between G1 and S phases and inhibits DNA synthesis. A C-to-T transition within this region creates a variant that alters mRNA function and has been shown to be associated with an increased breast cancer risk among young North Americans who are under 50 years and have at least one first-degree relative with breast cancer. We carried out a population-based case–control study to assess whether this association exists in Turkish women. We examined 106 breast cancer patients and 154 healthy controls by PCR and restriction fragment length polymorphism analysis. In the prohibitin 3′UTR, we did not detect a difference in CT/TT genotype frequency (p = 0.694; odds ratio [OR], 1.106; 95% confidence intervals [CI], 0.659–1.86) or in C/T allele frequency (p = 0.850; OR, 1.043; 95% CI, 0.667–1.62 … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |