The effects of pirfenidone on ischaemia-reperfusion injury in testicular torsion-induced rat model
Yazarlar (5)
Engin Kölükçü Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Fatih Firat Tokat State Hospital, Türkiye
Faik Alev Deresoy
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Muzaffer KATAR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Doğan ATILĞAN Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Andrologia | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 53 / 2 / 1–19 | DOI | 10.1111/and.13922 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/33244780/ | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| The aim of this study was to analyse the effect of pirfenidone against ischaemia–reperfusion injury occurring after detorsion in rats with induced testicular torsion model. Group 1 was assigned as the control group. Group 2 first had testis torsion performed, and then, testicular detorsion was performed. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 325 mg/kg pirfenidone administered immediately after ischaemia. The blood samples were analysed spectrophotometrically. To determine the intensity of tissue injury, haemorrhage, oedema and congestion levels were evaluated with direct microscopic investigation of testis. Seminiferous tubule architecture, spermatogenesis processes and germ cell maturation were graded by Johnsen and Cosentino scoring systems. In Group 3, superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px) activities increased compared … |
| Anahtar Kelimeler |
| ischaemia–reperfusion injury | pirfenidone | testicular torsion | treatment |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 27 |
| Google Scholar | 31 |