Synthesis, Characterization, and Molecular Docking Studies of Fluoro and Chlorophenylhydrazine Schiff Bases
Yazarlar (1)
Doç. Dr. Ayşegül ŞENOCAK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Journal of the Turkish Chemical Society Section A Chemistry | ||
| Dergi ISSN | 2149-0120 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 6 / 3 / 303–310 | DOI | 10.18596/jotcsa.535441 |
| Makale Linki | http://dergipark.org.tr/doi/10.18596/jotcsa.535441 | ||
| UAK Araştırma Alanları |
Anorganik Kimya
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| Özet |
| Six Schiff bases synthesized by condensation reaction of p-fluoro and chlorophenylhydrazines with some carbonyl compounds were reported in this work. Structures of the prepared compounds were elucidated by FT-IR, 1H- and 13 C-NMR spectroscopy. FT-IR spectra exhibited characteristic transitions for all compounds. Also, their structures were proved by NMR spectroscopy, especially with the imine peak which is an indicator of the formation of Schiff bases. In addition, molecular docking studies of the Schiff bases were carried out on Alzheimer’s disease. The calculated docking scores and inhibition constants pointed out the usage probability of 2-chloro-5-nitrobenzaldehyde Schiff bases as a new drug candidate for Alzheimer’s disease after structural regulations. |
| Anahtar Kelimeler |
| Alzheimer’s disease | Cholinesterases | Molecular docking | NMR spectroscopy | Phenylhydrazine | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 2 |