NRAMP1 SLC11A1 Variants Genetic Susceptibility to Multiple Sclerosis
Yazarlar (4)
Omer Ates
Semiha Kurt
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Hatice Karaer
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF CLINICAL IMMUNOLOGY | ||
| Dergi ISSN | 0271-9142 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2010 |
| Cilt / Sayı / Sayfa | 30 / 4 / 583–586 | DOI | 10.1007/s10875-010-9422-5 |
| Makale Linki | s10875-010-9422-5%20(1).pdf | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| ObjectivesMultiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. Human Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility.MethodsWe analyzed (GT)n, INT4, 3′UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis.ResultsNo significant association was found between (GT)n, INT4, 3′UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms.ConclusionsOur findings suggest that NRAMP1 polymorphisms do not play a role in MS … |
| Anahtar Kelimeler |
| NRAMP1 | multiple sclerosis | genetic susceptibilty | polymorphism |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Google Scholar | 15 |