Eco-friendly synthesis and characterization of silver nanoparticles using Juglans regia extract and their anti-Trichomonas vaginalis, anticancer, and antimicrobial effects
Yazarlar (5)
Erciyes Üniversitesi, Türkiye
Arş. Gör. Burak KÜÇÜK
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yozgat Bozok Üniversitesi, Türkiye
Bozok Üniversitesi, Türkiye
Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Anti Cancer Agents in Medicinal Chemistry |
| Dergi ISSN | 1871-5206 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2023 |
| Cilt No | 23 |
| Sayı | 20 |
| Sayfalar | 2189 / 2199 |
| DOI Numarası | 10.2174/1871520623666230309121801 |
| Makale Linki | http://dx.doi.org/10.2174/1871520623666230309121801 |
| Özet |
| Background: Green synthesis is an efficient and eco-friendly method that has been used frequently in silver nanoparticle production in recent years. This method facilitates the production of nanoparticles using various organ-isms, such as plants, and is also cheaper and easier to apply than the other techniques. Aims: This study aims to find possible mechanisms and pharmacological effects of cubic silver nanoparticles (AgNPs). Objectives: This study characterizes cubic AgNPs and describes in detail their anticancer, antimicrobial, and anti-Trichomonas vaginalis abilities. Methods: Silver nanoparticles were produced by green synthesis using Juglans regia (walnut) leaf aqueous extract. We validated the formation of AgNPs by UV-vis spectroscopy, FTIR analysis, and SEM micrographs. To determine the pharmacological effects of the AgNPs, we conducted anti-cancer, anti-bacterial, and anti-parasitic activity experiments. Results: Cytotoxicity data revealed that AgNPs have cellular inhibitory properties on cancerous MCF7 (breast), HeLa (cervix), C6 (glioma), and HT29 (colorectal) cell lines. Similar results are also obtained with anti-bacterial and anti-Trichomonas vaginalis activity experiments. At certain concentrations, AgNPs displayed stronger anti-bacterial activities than the sulbactam/cefoperazone antibiotic combination in five bacteria species. Furthermore, the 12-h AgNPs treatment exhibited satisfactory anti-Trichomonas vaginalis activity similar to the FDA-approved metronidazole. Conclusion: Consequently, AgNPs produced by the green synthesis method by Juglans regia leaves showed remarka-ble anti-carcinogenic, anti-bacterial, and anti-trichomonas vaginalis activities. We propose the potential usefulness of green synthesized AgNPs as therapeutics. |
| Anahtar Kelimeler |
| anti-bacterial | anti-carcinogenic | anti-Trichomonas vaginalis | green synthesis | Juglans regia | Silver nanoparticles |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |
| SCOPUS | 3 |
| Google Scholar | 4 |