Oxytocin for preventing injury due to testicular torsion/detorsion in rats
Yazarlar (6)
Fatih Fırat
Prof. Dr. Fikret ERDEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Engin KÖLÜKÇÜ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Fikret GEVREK Tokat Gaziosmanpaşa Üniversitesi, Türkiye
İsmail Benli
Doç. Dr. Velid Unsal Mardin Artuklu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY | ||
| Dergi ISSN | 1306-696X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2018 |
| Cilt / Sayı / Sayfa | 24 / 2 / 89–96 | DOI | 10.5505/tjtes.2017.25730 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/29569694/ | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| We aimed to demonstrate the effectiveness of oxytocin on the testes for treating ischemia-reperfusion injury. A total of 24 male Wistar albino rats weighing 250-320 g were used. The rats were randomized into three groups of eight rats. Group 1 was assessed as the control group. In Group 2 rats, testicular torsion was first performed, followed by testicular detorsion to induce reperfusion injury. In Group 3, following testicular torsion and detorsion, oxytocin was administered before inducing reperfusion. Testicular tissues were histologically evaluated, spermatogenic parameters were assessed using the Johnsen scoring system, and the mean Johnsen score was calculated. Histological tests revealed significantly different results between the testicular torsion group and the oxytocin-treated torsion and control groups as well as between the oxytocin-treated torsion group and the control and testicular torsion groups (p=0.010 and 0.012, respectively). Biochemical test results revealed that superoxide dismutase and glutathione peroxidase levels were significantly lower in Group 2 than in Group 1 (p=0.007 and 0.007, respectively). Malondialdehyde and nitric oxide levels were significantly lower in Group 3 than in Group 2 (p=0.017 and 0.014, respectively). These results indicate that oxytocin can be considered as an alternative agent for treating testicular torsion in clinical practice to minimize tissue damage. |
| Anahtar Kelimeler |
| I/R injury | oxytocin | torsion |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |