Effective Protection Against Status Epilepticus Caused by Lithium–Pilocarpine: Combination of Midazolam and Lacosamide
Yazarlar (6)
Cumaali Demirtas
Dr. Öğr. Üyesi Metehan AKÇA Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ugur Aykin
Yunus Emre Surmeneli
Hava Yildirim
Mehmet Yildirim
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BRAIN AND BEHAVIOR (Q2) | ||
| Dergi ISSN | 2162-3279 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 15 / 5 / – | DOI | 10.1002/brb3.70546 |
| Makale Linki | https://doi.org/10.1002/brb3.70546 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Aim Status epilepticus causes the most severe condition related to epilepsy in terms of high mortality rate. Although status epilepticus treatment guidelines specify a treatment process based on three‐stage monotherapy, effective control cannot yet be achieved in all cases. In the presented study, with electrophysiological and behavioral tests, it was aimed to investigate the effectiveness of the combination of midazolam (MDZ), one of the most commonly used benzodiazepines in the first‐line treatment of status epilepticus, with the second‐line antiepileptics levetiracetam (LEV), lacosamide (LCM), valproic acid (VPA), and fosphenytoin (fPHT). Methods A status epilepticus model was created with lithium–pilocarpine (5 mEq/kg–320 mg/kg) in adult male Sprague–Dawley rats with implanted electroencephalography (EEG) electrodes. MDZ (9 mg/kg) alone or in dual combinations with antiepileptic drugs (200 mg/kg … |
| Anahtar Kelimeler |
| fosphenytoin | lithium-pilocarpine | midazolam | status epilepticus | valproic acid |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 5 |