Efficacy of Low‐Dose Ketamine and Propofol in the Treatment of Experimental Refractory Status Epilepticus on Male Rats
Yazarlar (7)
Gaye Boztepe Yilmaz
Kemal Tolga Saracoglu
Ugur Aykin
Dr. Öğr. Üyesi Metehan AKÇA Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Cumaali Demirtas
Ayten Saracoglu
Mehmet Yildirim
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF NEUROSCIENCE RESEARCH (Q2) | ||
| Dergi ISSN | 0360-4012 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 11-2024 |
| Cilt / Sayı / Sayfa | 102 / 11 / – | DOI | 10.1002/jnr.25393 |
| Makale Linki | https://doi.org/10.1002/jnr.25393 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Refractory status epilepticus (RSE) is a condition with serious mortality and morbidity rate, resistant to benzodiazepine and second‐line antiepileptic drugs. This study aimed to electrophysiologically investigate the combination of NMDA receptor antagonist ketamine and GABAergic agent propofol in an RSE model induced by lithium‐pilocarpine in male Sprague–Dawley rats. Seventy‐two male Sprague–Dawley rats were divided into nine groups. The RSE model was induced by subcutaneous injection of lithium‐CI (5 mEq/kg) and intraperitoneal injection of pilocarpine‐HCl (320 mg/kg), after implanting tripolar EEG electrode. Ketamine (30, 60, and 90 mg/kg), propofol (20, 40, and 80 mg/kg), and combinations of both drugs (15 + 20 and 30 + 40 mg/kg) were administered intraperitoneally to animals with RSE. Video‐EEG recordings were taken after inducing model and 48 h later. The efficacy of drugs … |
| Anahtar Kelimeler |
| ketamine | lithium-pilocarpine | propofol | status epilepticus |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Google Scholar | 4 |