Investigating the mechanism of action of ginkgolides and bilobalide on absence seizures in male WAG/Rij rats
Yazarlar (3)
Öznur Gedikli Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF NEUROSCIENCE RESEARCH (Q2) | ||
| Dergi ISSN | 0360-4012 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 101 / 6 / 866–880 | DOI | 10.1002/jnr.25166 |
| Makale Linki | http://dx.doi.org/10.1002/jnr.25166 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| The effects of a single and multiple doses of ginkgolide A, B, C, and bilobalide, active components of Ginkgo biloba extract (EGb 761), on absence seizures were investigated in male WAG/Rij rats, a genetic animal model of absence epilepsy. Furthermore, the interactions of ginkgolide A together with NMDA receptor antagonist MK‐801, AMPA/kainate receptor antagonist 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX), or L‐type calcium channel blocker nicardipine were studied to figure out how ginkgolide A affects spike–wave discharges (SWDs) in the brain. The experiments were done using 6–8‐month‐old male WAG/Rij rats with infusion cannula and EEG electrode implanted. Ginkgolide A, B, C, and bilobalide were administered intraperitoneally for 7 days at a dose of 6 mg/kg. In interaction groups, 6 μg ginkgolide A was injected intracerebroventricularly in combination with MK‐801 (10 μg), CNQX (1 μg), and … |
| Anahtar Kelimeler |
| bilobalide | Ginkgo biloba | ginkgolides | spike-wave discharges | WAG | Rij rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Google Scholar | 5 |