Electroencephalographic investigation of the effects of Ginkgo biloba on spike-wave discharges in rats with genetic absence epilepsy
Yazarlar (3)
Öznur Gedikli Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | EPILEPSY & BEHAVIOR (Q2) | ||
| Dergi ISSN | 1525-5050 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2021 |
| Cilt / Sayı / Sayfa | 122 / 0 / 108165–0 | DOI | 10.1016/j.yebeh.2021.108165 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/34343959/ | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| ObjectiveEGb 761, a plant extract obtained from the leaves of the Ginkgo biloba tree, is widely used in modern medicine and traditional medicine applications in the treatment of many diseases. However, in some clinical case reports, it has been suggested that G. biloba causes epileptic seizures. A limited number of experimental animal studies related to the effects of G. biloba on epileptic seizures do not provide sufficient information on the solution of a serious clinical problem with contrasting findings. We aimed to investigate the effects of EGb 761 administered in different doses to adult male Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats which is the genetic animal model of absence epilepsy, on absence seizures using in vivo electrophysiological method. In addition, the effects of EGb 761 doses on locomotor behavior of WAG/Rij rats were evaluated with open-field and rotarod behavioral tests.Methods50, 100, 200 … |
| Anahtar Kelimeler |
| Absence epilepsy | EEG | Ginkgo biloba | Spike-wave discharge | WAG | Rij rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Google Scholar | 8 |