Combination Therapy of Gabapentin and N-Acetylcysteine Against Posttraumatic Epilepsy in Rats
Yazarlar (6)
Mustafa Efendioglu
Recep Basaran
Duygu Ceman
Cumaali Demirtas
Mehmet Yildirim
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NEUROCHEMICAL RESEARCH (Q2) | ||
| Dergi ISSN | 0364-3190 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2020 |
| Cilt / Sayı / Sayfa | 45 / 8 / 1802–1812 | DOI | 10.1007/s11064-020-03042-x |
| Makale Linki | http://link.springer.com/10.1007/s11064-020-03042-x | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Traumatic brain injury (TBI) is a major public health problem worldwide that is associated with increased mortality and morbidity. Posttraumatic epilepsy (PTE) is one of the sequelae of TBI. The aim of this study was to investigate the role of N-acetylcysteine (NAC) as an adjuvant on the efficacy of levetiracetam (LEV) and gabapentin (GBP) in PTE model encouraged by pentylenetetrazol (PTZ) after mild-TBI in male Sprague–Dawley rats. Mild-TBI was performed by the weight-drop method in male Sprague–Dawley rats. PTE model was developed by injecting PTZ (30+15+15 mg/kg, 30 min intervals, i.p.) 7 days after head trauma. After the development of posttraumatic seizures, the rats were treated with NAC (100 mg/kg), LEV (50 mg/kg), GBP (100 mg/kg), NAC+LEV and NAC+GBP intraperitoneally for 14 days. Seizures related to PTE were scored by video-EEG recording. Motor performance of the animals was also … |
| Anahtar Kelimeler |
| Traumatic brain injury | Posttraumatic epilepsy | Levetiracetam | Gabapentin | N-Acetylcysteine |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Google Scholar | 18 |