Ischemia-modified albumin and the IMA/albumin ratio in the dignosis and staging of hemorrhagic shock: A randomized controlled experimental study
Yazarlar (11)
Prof. Dr. Süleyman Türedi Karadeniz Teknik Üniversitesi, Türkiye
Öğr. Gör. Aynur Şahin Karadeniz Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Selim Demir Karadeniz Teknik Üniversitesi, Türkiye
Gökçen Derya Reis Köse
Dr. Öğr. Üyesi Arif Burak Çekiç Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Esin Yuluğ Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Ahmet Menteşe Karadeniz Teknik Üniversitesi, Türkiye
Süha Türkmen
Türkiye
Türkiye
Sami Acar
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY | ||
| Dergi ISSN | 1306-696X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2020 |
| Cilt / Sayı / Sayfa | 26 / 2 / 153–162 | DOI | 10.14744/tjtes.2019.32754 |
| Makale Linki | https://jag.journalagent.com/travma/pdfs/UTD-32754-RESEARCH_ARTICLE-TUREDI.pdf | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| BACKGROUND: To determine the value of ischemia-modified albumin (IMA) and IMA/albumin ratio (IMAR) in the diagnosis and staging of hemorrhagic shock (HS).METHODS: A pressure-targeted HS model was established in this study. The control and shock groups were monitored for 30 min and 60 min to simulate varying durations of exposure to HS. All subjects underwent invasive arterial monitoring during the experiment and were further divided into mild and severe shock groups based on decreases in mean arterial pressure (MAP). Biochemical and histologic comparisons were performed between the groups.RESULTS: Our results revealed higher IMA, IMAR, lactate, total oxidant status (TOS) and oxidative stress index (OSI) levels in both the 30-and 60-min shock groups compared to the control group. Concerning MAP-based shock staging, IMA, IMAR, lactate, TOS and OSI levels in the 30-min and 60-min mild and severe shock groups were higher than those of the controls. However, there was no significant difference between the mild and severe shock groups. A significant correlation was determined between all the biomarkers evaluated and HS-induced damage in various organs. This correlation was highest in lactate and IMAR levels.CONCLUSION: IMA and IMAR levels may be used in the early diagnosis of HS and also have the potential for use in determining the severity of HS. IMA and IMAR measurement may also be considered as an alternative or in addition to lactate measurement in the diagnosis of HS. |
| Anahtar Kelimeler |
| Albumin | hemorrhage | ischemia modified albumin | hemorrhagic shock | lactate | trauma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Google Scholar | 12 |