Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: An electrophysiological study
Yazarlar (6)
Prof. Dr. Tevfik Yılmaz Dicle Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Arş. Gör. Yahya Turan Dicle Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hakan Ocak Karadeniz Teknik Üniversitesi, Türkiye
Kağan Kamaşak
Hitit Üniversitesi, Türkiye
Hitit Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BRAIN RESEARCH | ||
| Dergi ISSN | 0006-8993 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2014 |
| Cilt / Sayı / Sayfa | 1554 / 0 / 67–72 | DOI | 10.1016/j.brainres.2014.01.040 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0006899314001073 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Corticosteroids are extensively used in treatment of many diseases. In neurosurgery practice, dexamethasone (DEX) is commonly used particularly in cerebral edema secondary to brain tumors, head trauma, and central nervous system infections. There are some uncertainties surrounding the secure use of DEX in patients with epilepsy or seizures induced by diseases of the central nervous system such as head trauma and brain tumors. Despite its extensive use, the effect of DEX on epileptiform activity is unclear. In this study the effect of DEX on epileptiform activity was investigated in rats. The effects of 1, 3, and 10 mg/kg DEX on epileptiform activity was compared with effects of antiepileptic drugs commonly employed in treatment of epilepsy, namely phenytoin (PHT) 50 mg/kg and levetiracetam (LEV) 50 mg/kg that were administered intraperitoneally for 1 week. All groups were administered intracortical penicillin … |
| Anahtar Kelimeler |
| Dexamethasone | Phenytoin | Levetiracetam | Experimental epilepsy | Penicillin | Rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Google Scholar | 12 |