Electrophysiological evidence for the anticonvulsant effect of alpha-lipoic acid via indirect antioxidant properties in BALB/c mice
Yazarlar (3)
Dr. Öğr. Üyesi Mukadder Okuyan Karadeniz Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NEUROLOGICAL RESEARCH | ||
| Dergi ISSN | 0161-6412 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2013 |
| Cilt / Sayı / Sayfa | 35 / 7 / 726–733 | DOI | 10.1179/1743132813Y.0000000188 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.1179/1743132813Y.0000000188 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Alpha-lipoic acid (alpha-LA) is a strong antioxidant whose effect on epilepsy has not been completely clarified yet. The present study was designed to investigate the effects of alpha-LA on epileptiform activity induced by penicillin in BALB/c mice.In the present study, 56 adult male BALB/c mice were divided into seven groups. Under urethane anesthesia, the mice were injected with intracortical (i.c.) 200 IU penicillin following craniotomy to start epileptiform activity. The effects of alpha-LA on epileptiform activity were examined through the intraperitoneal (i.p.) application of 25, 50, 100, 200, and 400 mg/kg doses. The electrophysiological data have demonstrated that alpha-LA at the 200 mg/kg dose showed an anticonvulsant effect by reducing penicillin-induced epileptiform activity. This effect obtained at the 200 mg/kg dose was determined to emerge 80 minutes after injection (i.p.) and last throughout the experiment … |
| Anahtar Kelimeler |
| Alpha-lipoic acid | Electrocorticogram | Epileptiform activity | Penicillin | Mice |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |