Evaluation of the Role of Chronic Daily Melatonin Administration and Pinealectomy on Penicillin-Induced Focal Epileptiform Activity and Spectral Analysis of ECoG in Rats: An In Vivo Electrophysiological Study
Yazarlar (6)
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
Selcen Aydin-Abidin
Prof. Dr. İsmail Abidin Karadeniz Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Prof. Dr. Sinan Canpolat Fırat Üniversitesi, Türkiye
Prof. Dr. Ali Cansu Karadeniz Teknik Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NEUROCHEMICAL RESEARCH | ||
| Dergi ISSN | 0364-3190 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2013 |
| Cilt / Sayı / Sayfa | 38 / 8 / 1672–1685 | DOI | 10.1007/s11064-013-1069-1 |
| Makale Linki | http://link.springer.com/10.1007/s11064-013-1069-1 | ||
| UAK Araştırma Alanları |
Fizyoloji
|
||
| Özet |
| In the present study, we aimed to investigate the effects of pinealectomy and chronic melatonin administration on focal epileptiform activity induced by penicillin in the rat cortex and to determine the relation between melatonin levels and electrocorticogram (ECoG) power spectrum. For this purpose, male Sprague-Dawley rats were divided into six groups: control, sham operated, ethanol, melatonin, pinealectomy and pinealectomy + melatonin group. Melatonin-treated rats was intraperitoneally injected with a daily single dose of 10 mg/kg melatonin for 14 days, but the last dose was given 30 min after local application of penicillin as a convulsant agent. Focal epileptiform activity was produced by intracortical administration of penicillin (200 units/1 μl). While chronic melatonin application did not affect either the onset latency or the spike frequency of epileptiform activity, pinealectomy significantly reduced latency to … |
| Anahtar Kelimeler |
| Melatonin | Pinealectomy | Electrocorticogram | Epileptiform activity | Power spectrum | Penicillin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Google Scholar | 12 |