Is grayanotoxin directly responsible for mad honey poisoning-associated seizures
Yazarlar (8)
Prof. Dr. Abdülkadir Gündüz Karadeniz Teknik Üniversitesi, Türkiye
Murat Aydın
Dr. Öğr. Üyesi Metehan AKÇA Sağlık Bilimleri Üniversitesi, Türkiye
Süha Türkmen
Acıbadem Üniversitesi, Türkiye
Acıbadem Üniversitesi, Türkiye
Prof. Dr. Süleyman Türedi Karadeniz Teknik Üniversitesi, Türkiye
Umut Eryiğit
Karadeniz Teknik Üniversitesi, Türkiye
Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Ali Cansu Karadeniz Teknik Üniversitesi, Türkiye
Prof. Dr. Mehmet Yıldırım Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | TURKISH JOURNAL OF MEDICAL SCIENCES | ||
| Dergi ISSN | 1300-0144 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2012 |
| Cilt / Sayı / Sayfa | 42 / 6 / 1086–1092 | DOI | 10.3906/sag-1201-14 |
| Makale Linki | https://journals.tubitak.gov.tr/medical/vol42/iss6/22/ | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| The aim of this study was to investigate the effects of grayanotoxin on epileptiform activity in rats. Materials and methods Forty-two male Sprague Dawley rats were equally divided into 1 of 7 groups. Thirty minutes after induction of epileptiform activity induced by penicillin injection, 0.5, 1, 2, 4, or 8 µg of grayanotoxin-III was intracerebroventricularly administered. Epileptiform activity spike frequency and amplitude were converted into numerical data using software following the experiment. Results Our results show that grayanotoxin reduces epileptiform spike frequency and amplitude in a dose-dependent manner. Five minutes postinjection, grayanotoxin significantly reduced epileptiform activity, especially at higher doses. This acute effect subsequently declined, but a dose-dependent decrease was observed through the end of the experiment. This suggests that the first observed effect of grayanotoxin on spikes probably consists of blocking voltage-gated sodium channel inactivation. Conclusion Grayanotoxin's suppression of epileptiform activity in this experimental study indicates that grayanotoxin is not directly responsible for mad honey poisoning-associated seizures observed in a clinical context. |
| Anahtar Kelimeler |
| Grayanotoxin | mad honey | seizure | experimental epilepsy | ECoG | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Google Scholar | 13 |