Penicillin induced epileptiform activity and EEG spectrum analysis of BDNF heterozygous mice: An in vivo electrophysiological study
Yazarlar (7)
Ismail Abidin
Mehmet Yildirim
Selcen Aydin-Abidin
Ersan Kalay
Ali Cansu
Thomas Mittmann
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | BRAIN RESEARCH BULLETIN | ||
| Dergi ISSN | 0361-9230 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2011 |
| Cilt / Sayı / Sayfa | 86 / 3 / 159–164 | DOI | 10.1016/j.brainresbull.2011.06.015 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0361923011001961 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Brain-derived neurotrophic factor (BDNF) heterozygous mice (BDNF (+/−)) kindle slowly and have a higher seizure threshold. However, BDNF (+/−) mice exhibit reduced cortical inhibition and disrupted balance of excitation/inhibition synaptic transmission. We investigated penicillin-induced focal cortical epileptiform activity and electroencephalogram (EEG) spectral power of BDNF (+/−) mice, by using electrocorticogram (ECoG) recordings. BDNF (+/−) mice (n=10) and wild type littermates (n=9) were anesthetized with i.p. urethane (1.750g/kg). The recordings of ECoG were carried out by using a data acquisition system and 100IU penicillin was administered intracortically to induce epileptiform activity. The latencies for the onset of spikes and the amplitude of the spikes showed no differences. However the frequency of the spikes was significantly lower in BDNF (+/−) mice at 40th and 45thmin following penicillin … |
| Anahtar Kelimeler |
| BDNF | Experimental epilepsy | Cortex | EEG | Mice |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Google Scholar | 17 |