Garcinoic acid enhances inflammation resolution against colitis by activating Nrf2 dependent efferocytosis.
Yazarlar (9)
Öğr. Gör. İbrahim İSOT Marmara Üniversitesi Tip Fakültesi, Türkiye
Seong Hoon Kim
College Of Pharmacy, Güney Kore
College Of Pharmacy, Güney Kore
Tugce Demirel-Yalciner
Üsküdar Üniversitesi, Türkiye
Üsküdar Üniversitesi, Türkiye
Anna Migni Università Degli Studi Di Perugia, İtalya
Antimo Gioiello Università Degli Studi Di Perugia, İtalya
Francesco Galli Università Degli Studi Di Perugia, İtalya
Erdi Sozen
Marmara Üniversitesi Tip Fakültesi, Türkiye
Marmara Üniversitesi Tip Fakültesi, Türkiye
Young-Joon Surh
College Of Pharmacy, Güney Kore
College Of Pharmacy, Güney Kore
Prof. Dr. Nesrin Kartal Ozer Üsküdar Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Free Radical Biology and Medicine (Q1) | ||
| Dergi ISSN | 0891-5849 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Cilt / Sayı / Sayfa | 237 / 1 / 37–45 | DOI | 10.1016/j.freeradbiomed.2025.05.428 |
| UAK Araştırma Alanları |
Tıbbi Biyokimya
|
||
| Özet |
| Inflammation resolution represents the most crucial step in the inflammatory response, and its disruption is associated with a variety of disorders. Clearance of apoptotic cells, namely efferocytosis, plays a pivotal role in this process by preventing the transition of apoptotic cell accumulation into necrosis and fibrosis. Garcinoic acid (GA), a plant metabolite and a postbiotics analogue of vitamin E, has been demonstrated to possess anti-inflammatory activity, but mechanistic aspects of this effect remain poorly characterized. In this study, we explored the potential of GA in enhancing efferocytosis and inflammation resolution. In vitro findings using macrophages indicated that GA enhances efferocytosis through the involvement of MerTK, LRP-1, and TIM4, and specialized pro-resolving lipid mediators (SPMs), mainly lipoxin A4 and resolvin E1. As in vivo, GA reduced inflammatory and degenerative symptoms in a mouse … |
| Anahtar Kelimeler |
| DSS-Induced colitis | Efferocytosis | Garcinoic acid | Inflammation | Macrophage |
Science Direct
Garcinoic acid enhances inflammation resolution against colitis by activating Nrf2 dependent efferocytosis.
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 3 |
| Google Scholar | 3 |