Impact of glucocorticoid receptor gene Bcl-1 variant on temporomandibular disorders
Yazarlar (6)
Prof. Dr. Mehmet Kemal Tumer Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Kaan Yerliyurt Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Ayse Nursal
Hitit University, Türkiye
Hitit University, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Akin Tekcan Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Serbulent Yigit Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biomedical Research India | ||
| Dergi ISSN | 0970-938X | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2017 |
| Cilt / Sayı / Sayfa | 28 / 20 / 8696–8701 | DOI | – |
| Makale Linki | https://www.researchgate.net/profile/Serbulent-Yigit/publication/322355542_Impact_of_glucocorticoid_receptor_gene_Bcl-1_variant_on_temporomandibular_disorders/links/5a72d3a2a6fdcc53fe132303/Impact-of-glucocorticoid-receptor-gene-Bcl-1-variant-on-temp | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objectives Temporomandibular Disorders (TMD) constitute a heterogeneous group of disorders characterized by alterations in mandibular movement. The aim of this study was to investigate the association between the Bcl1 variant of NR3C1 gene and TMD susceptibility in Turkish population. Method NR3C1 gene BcI1 variant of 100 TMD patients and 105 healthy controls was genotyped by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). Results There was also no significant difference in regard to genotype and allele frequencies between the patients and the controls (OR 0.216 (95% Cl: 0.85-2.04); p= 0.216). However, present study found that numeric pain rating scale was higher in patients with CC and CG genotypes. Discussion Although the NR3C1 Bcl1 variant did not show any difference between the TMD and the control groups, we thought that this variant could be correlated with pain intensity in patients. Further studies with different ethnic subjects are needed to confirm the results. |
| Anahtar Kelimeler |
| Bcl1 variant | Glucocorticoid receptor gene | Temporomandibular disorders |
