GABA-mediated hyperalgesic effect of tranexamic acid.
Yazarlar (10)
Ferda Serdoğan
Kemal Tolga Saraçoğlu
Uğur Aykın
Dr. Öğr. Üyesi Metehan AKÇA Türkiye
Cumaali Demirtaş
Yunus Emre Sürmeneli
Elif Akova
Ayten Saraçoğlu
Tamer Kuzucuoğlu
Mehmet Yıldırım Tokat Gaziosmanpaşa Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Anatomy: International Journal of Experimental & Clinical Anatomy | ||
| Makale Dili | – | Basım Tarihi | 10-2022 |
| Cilt / Sayı / Sayfa | 16 / 0 / – | DOI | – |
| Makale Linki | https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=13078798&AN=163783483&h=LVdVuWTxa7glgcmTWhs7hbizznkiT7ADgzJ2Gr5GVvBP0f2gvu6fOuMvF68VC50YgR45aPENozmnDKurgXgc3w%3D%3D&crl=c | ||
| UAK Araştırma Alanları |
Fizyoloji
|
||
| Özet |
| Objective: It has been reported in clinical studies that tranexamic acid (TXA), used as an antifibrinolytic agent, may cause postoperative hyperalgesia. However, there is no evidence in the literature regarding mechanisms by which TXA performs this effect. In the presented experimental study, it was aimed to behaviorally examine mechanism of action of TXA for development of pain through GABA and glycine receptors. Methods: A total of 64 male Sprague-Dawley rats were divided into 8 groups and used in the experiments (SBU-HADYEK-2020-03/03). Dynamic plantar test was used to determine pain threshold of the animals, and open field and rotarod tests were used to examine the motor behaviors. Experimental groups were given physiological saline (control), 1 mg/kg TXA, 5 mg/kg TXA, 25 mg/kg TXA, 100 mg/kg gabapentin (GABA receptor analogue), 300 mg/kg taurine (glycine receptor agonist), 100 mg/kg … |
| Anahtar Kelimeler |
