Composition of the vaginal microbiota in relation to cervical intraepithelial lesions
Yazarlar (9)
Ethem Serdar Yalvaç
Çağlayan Ateş
Doç. Dr. Mustafa Numan BAKIRCI Türkiye
Emine Yeşilyurt Şölen
Fulya Kayıkçıoğlu
Sevgi Koç
Ayşe Erbay
Demet Aydoğan Kırmızı
Taylan Onat Tokat Gaziosmanpaşa Üniversitesi
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Turkish Journal of Obstetrics and Gynecology | ||
| Makale Dili | – | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 22 / 3 / 220–0 | DOI | – |
| Makale Linki | https://pmc.ncbi.nlm.nih.gov/articles/PMC12411972/ | ||
| UAK Araştırma Alanları |
Yüksek Enerji ve Parçacık Fiziği
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| Özet |
| Objective This study aimed to investigate the relationship between cervical intraepithelial neoplasia associated with human papillomavirus (HPV) infection and the vaginal microbiome. Materials and Methods In this study, the vaginal microbiota profile was compared among three groups of women: those with HPV infection and no cervical intraepithelial neoplasia (NILM, n=35), those with low-grade squamous intraepithelial lesions (LSIL, n=28), and those with high-grade squamous intraepithelial lesions (HSIL, n=24). Vaginal bacterial diversity was analyzed by deep sequencing of the V3-4 region of the barcoded 16S rRNA gene using the Illumina MiSeq platform, considering alpha diversity, beta diversity, and taxon classifications. Statistical significance was set at p<0.05. Results In the analyses performed using Chao1, Inverse Simpson, Shannon, and Observed indices, statistically significant differences were found … |
| Anahtar Kelimeler |
