Effects of melatonin on partial unilateral ureteral obstruction induced oxidativeinjury in rat kidney
Yazarlar (7)
Atilgan Dogan
S Parlaktas Bekir
Uluocak Nihat
Erdemir Fikret
Firat Fatih
Erkorkmaz Unal
Saylan Oguzhan
| Makale Türü | Özgün Makale (Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale) | ||
| Dergi Adı | Urology Annalls | ||
| Dergi Tarandığı Indeksler | index copernicus | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2012 |
| Cilt / Sayı / Sayfa | – / 2 / – | DOI | – |
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| Aim:This experimental study was designed to produce ischemia-reperfusion injury in rat kidney by performing partial unilateral ureteral obstruction (PUUO) and investigated the effects of melatonin on the levels of oxidative injury parameters.Materials and Methods:Twenty-four adult male rats were randomly divided into three groups as follows; control group (Group 1); only nephrectomy and blood (5 ml) drawn from vena cava inferior, PUUO group (Group 2); PUUO (10 days)+ ipsilateral nephrectomy after recovery of PUUO+ blood from vena cava inferior VCI, melatonin treated group (Group 3); PUUO (10 days)+ melatonin (1/2 hr before release, 50 mg/kg, ip)+ ipsilateral nephrectomy after recovery of PUUO+ blood from VCI. The left ureter was embedded into the psoas muscle to create PUUO. After 10 days, PUUO was recovered and ipsilateral nephrectomies were performed for biochemical analysis of superoxide … |
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