Importance of Genetic Polymorphisms (Rs662 and Rs854560) of the Paraoxonase-1 Gene as Risk Factor for Acute Ischemic Stroke in Turkish Population
Yazarlar (7)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nurşah Başol Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Ondokuz Mayıs Üniversitesi, Türkiye
Pınar Çoğaş
Tuba Ceviz
Ali Kablan
Dr. Öğr. Üyesi Osman DEMİR Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Critical Care and Emergency Medicine | ||
| Dergi ISSN | 2474-3674 | ||
| Dergi Tarandığı Indeksler | Crossref | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2019 |
| Cilt / Sayı / Sayfa | 5 / 6 / – | DOI | 10.23937/2474-3674/1510094 |
| Makale Linki | https://www.clinmedjournals.org/articles/ijccem/international-journal-of-critical-care-and-emergency-medicine-ijccem-5-094.php?jid=ijccem | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Introduction: Ischemic stroke is account for most of the mortality and morbidity cases around the World. Paraoxonase-1 (PON1) is a significant candidate gene for ischemic stroke because of its function against atherosclerosis.Methods: We studied two common polymorphisms (Q192R [rs662] and L55M [rs854560]) of PON1 gene using PCR-based RFLP assay. Overall, 107 patients diagnosed as acute ischemic stroke and 99 healthy controls were enrolled in the present study. We also carried out a meta-analysis containing 3 case-control studies from Turkey.Results: Allele frequencies of PON1 gene Q192R and L55M polymorphisms didn’t demonstrate any significant differences between patients and controls (p> 0.05). However, genotype frequencies were significantly different between patients and controls in terms of Q192R polymorphism (p= 0.030). Statistically significant correlations were observed between systolic and diastolic blood pressures of patients and L55M polymorphism (p= 0.017 and p= 0.039, respectively). Heterozygosity for the both Q192R and L55M polymorphisms demonstrated a statistically significant association with acute ischemic stroke in composite genotype analyses (p= 0.033). The results of meta-analysis showed a significant correlation between acute ischemic stroke and the PON1 gene L55M polymorphism in Turkish population.Conclusion: PON1 gene Q192R and L55M polymorphisms may have effects on acute ischemic stroke susceptibility in Turkish population. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |