Evaluation of Protein C Gene Polymorphism in Patients with Diagnosis of Pulmonary embolism in Turkish Population
Yazarlar (4)
Tuba Ceviz
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nurşah Başol Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (Diğer hakemli uluslarası dergilerde yayınlanan tam makale) | ||
| Dergi Adı | J Clin Exp Invest | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 8 / 1 / 8–14 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objective Pulmonary embolism is usually a complication of deep vein thrombosis (DVT) and develops as a result ofobstruction of pulmonary artery and/or branches with pieces that ruptured from the DVT of the leg. Pulmonary embolismand DVT is also referred as venous thrombo-embolism (VTE), because two events often remain together. In the studies,it was found that protein C (PROC) deficiency is a risk factor for pulmonary embolism. In this study, we aimed toevaluate the association between pulmonary embolism and PROC gene -1654C>T polymorphism in Turkishpopulation.Methods The DNAs of 114 pulmonary embolism cases and 120 healthy controls have been analyzed by polymerasechain reaction (PCR) and restriction fragment length polymorphism (RFLP) to evaluate the relation between PROCgene -1654C>T polymorphism and pulmonary embolism in our study. Statistical analyses were performed by using chisquareand analysis of variance tests.Results The proportion of individuals with CT genotype carrying polymorphic T allele as heterozygous form was 38.7%in the control group and 21.9% in the pulmonary embolism cases (p=0.047). When demographic and clinicalcharacteristics of cases compared with PROC gene -1654C>T polymorphism, it was observed that the changes inchest CT ratios could be associated with -1654C>T polymorphism (p=0.017).Conclusion As a result, individuals with CT genotypes carrying the polymorphic T allele as heterozygous form havea lower risk of developing pulmonary embolism. |
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