Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer
Yazarlar (6)
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Nurten Kara
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Ali Naki Ulusoy
Özaslan Cihangir
Prof. Dr. Şengül Tural Ondokuz Mayıs Üniversitesi, Türkiye
İsmail Okan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Oncol Res Treat | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2015 |
| Cilt / Sayı / Sayfa | 38 / 9 / 418–422 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Background Polymorphisms of estrogen synthesis-and adiposity-related genes can contribute to the development of breast cancer. The purpose of the current study was to analyze the association between CYP17A1 T27C (rs743572) and LEP-2548G> A (rs7799039) gene polymorphisms and breast cancer. Material and Methods 199 breast cancer patients and 197 healthy controls were included in the study. The CYP17A1 and LEP gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism analysis. Results No statistically significant association was found between these polymorphisms and breast cancer risk among a Turkish population. However, stratified analysis of these polymorphisms in relation to different clinicopathological characteristics of breast cancer revealed an association between breast cancer diagnosis and the CYP17A1 T27C … |
| Anahtar Kelimeler |
