Tumor Necrosıs Factor Alpha Beta and Interferon Gamma Gene Polymorphisms in Turkish Breast Cancer Patients
Yazarlar (5)
Doç. Dr. Nevin KARAKUŞ Gaziosmanpaşa Üniversitesi, Türkiye
Nurten Kara Ondokuz Mayıs Üniversitesi, Türkiye
Ulusoy Ali Naki
Özaslan Cihangir
Yüksel Bek Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | DNA Cell Biol | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2011 |
| Cilt / Sayı / Sayfa | 30 / 6 / 371–377 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
|
||
| Özet |
| Cytokine genes are important for researching cancer predisposition to cancers that elicit anti-tumor immune response. In this study, we investigated the association between breast cancer and tumor necrosis factor alpha (TNF-α) −308 (G>A), TNF-β +252 (A>G), and interferon gamma (IFN-γ) +874 (T>A) gene polymorphisms in a Turkish population. This study involved 204 female breast cancer patients and 204 healthy female controls. Genomic DNA was extracted from EDTA-preserved peripheral venous blood of patients and controls by a salting-out method and analyzed by polymerase chain reaction, allele-specific oligonucleotide polymerase chain reaction, and restriction fragment length polymorphism. TNF-α −308 genotype was found to have no effect on breast cancer susceptibility. However, there were statistically significant differences between the genotype frequencies of patients and controls for TNF-β … |
| Anahtar Kelimeler |
