Association Between 1603C T Polymorphism of DBH Gene and Bipolar Disorder in a Turkish Population
Yazarlar (5)
Prof. Dr. Hacı Ömer ATEŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Feryal Çelikel Gaziosmanpaşa Üniversitesi, Türkiye
Serap Erdoğan Taycan
Dr. Öğr. Üyesi Saime Sezer Sondaş Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2013 |
| Cilt / Sayı / Sayfa | 519 / 2 / 356–359 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| OBJECTIVES Dopamine-β-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Bipolar disorder is a major psychiatric disorder. The present study was designed to explore the associations of polymorphisms of DBH gene in Turkish patients with bipolar disorder. METHODS −1021C>T (rs1611115) polymorphism in promoter region, 444G>A (rs1108580) polymorphism in exon 2 and 1603C>T (rs6271; C535R) polymorphism in exon11 of DBH gene were analyzed in 106 patients with bipolar disorder and 106 healthy subjects by using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS The results showed statistically significant associations for genotypic and allelic distribution between the 1603C>T polymorphism … |
| Anahtar Kelimeler |
