The association between Interleukin IL 4 gene intron 3 VNTR polymorphism and alopecia areata AA in Turkish population
Yazarlar (7)
Prof. Dr. Göknur Kalkan Yıldırım Beyazıt Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Yalçın Baş
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Takçı Zennure
Pınar Özuğuz Afyon Kocatepe Üniversitesi, Türkiye
Prof. Dr. Hacı Ömer ATEŞ Tokat Gaziosmanpaşa Üniversitesi, Türkiye
Prof. Dr. Serbülent Yiğit Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gene | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2013 |
| Cilt / Sayı / Sayfa | 527 / 2 / 565–569 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| ObjectiveAlopecia areata (AA) is hypothesized to be an organ-specific autoimmune disease of hair follicles mediated by T cells. As immunological and genetic factors have been implicated in the pathogenesis of AA, the purpose of the present study was to investigate possible associations between the functional Interleukin (IL)-4 gene intron 3 VNTR polymorphism and AA susceptibility and disease progression in Turkish population.MethodsThe study group consisted of 116 unrelated patients with AA and 125 unrelated healthy controls. Genomic DNA was isolated and IL-4 gene 70 bp VNTR polymorphism determined by using polymerase chain reaction (PCR) with specific primers.ResultsNo association was observed between AA patients and controls according to genotype distribution (p = 0.051). The allele distribution of IL-4 gene intron 3 VNTR polymorphism was statistically different between AA patients and … |
| Anahtar Kelimeler |
