Common Mediterranean fever MEFV gene mutations associated with ankylosing spondylitis in Turkish population
Yazarlar (5)
Prof. Dr. Serbülent Yiğit Gaziosmanpaşa Üniversitesi, Türkiye
Ahmet İnanır Gaziosmanpaşa Üniversitesi, Türkiye
Doç. Dr. Nevin KARAKUŞ Gaziosmanpaşa Üniversitesi, Türkiye
Esra Kesici
Gaziosmanpaşa Üniversitesi, Türkiye
Gaziosmanpaşa Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nihan BOZKURT Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Dis Markers | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 33 / 3 / 113–118 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease. Mediterranean fever (MEFV) gene, which has already been identified as being responsible for familial Mediterranean fever (FMF), is also a suspicious gene for AS because of the clinical association of these two diseases. The aim of this study was to explore the frequency and clinical significance of MEFV gene mutations (M694V, M680I, V726A, E148Q and P369S) in a cohort of Turkish patients with AS. Genomic DNAs of 103 AS patients and 120 controls were isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. There was a statistically significant difference of the MEFV gene mutation carrier rates between AS patients and healthy controls (p = 0.004, OR: 2.5, 95% CI: 1.32–4.76). This association was also observed in allele frequencies (p = 0.005, OR: 2.3, 95% CI: 1 … |
| Anahtar Kelimeler |
