The Evaluation of Angiotensin converting Enzyme ACE Gene I D and IL 4 Gene Intron 3 VNTR Polymorphisms in Coronary Artery Disease
Yazarlar (5)
Basol Nursah
Atac Celik
Nevin Karakus
Sd Ozsoy
S Yigit
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | In Vivo | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2014 |
| Cilt / Sayı / Sayfa | 28 / 5 / 983–987 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
|
||
| Özet |
| Background/Aim Genetic polymorphism is a strong risk factor for coronary artery disease (CAD). In the present study, our aim was to evaluate angiotensin-converting enzyme (ACE) gene I/D polymorphism and interleukin-4 (IL-4) gene Intron 3 variable number of tandem repeat (VNTR) polymorphism in CAD. Materials and Methods One hundred and twenty-four CAD patients and one hundred and twenty-three controls were enrolled. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses. Results The risk associated with inheriting the combined genotypes for the two polymorphisms were evaluated and it was found that the individuals who were P2P2-homozygous at IL-4 gene intron 3 VNTR and DD-homozygous at ACE gene I/D have a higher risk of developing CAD. Conclusion Although, there is no correlation between IL4 VNTR polymorphism and ACE gene polymorphism … |
| Anahtar Kelimeler |
