Association analysis of three ABCB1 MDR1 gene variants C1236T G2677A T and C3435T and their genotype haplotype combinations with the familial Mediterranean fever
Yazarlar (6)
Aydin Rustemoglu
Akay Guvem Gumus
Nevin Karakus
S Yigit
S Sahin
T Tasliyurt
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Xenobiotica | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2014 |
| Cilt / Sayı / Sayfa | 44 / 10 / 933–940 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| 1. Familial Mediterranean fever (FMF) is considered an autosomal recessive disorder, associated with a single gene named Mediterranean fever (MEFV). The aim of this study was to perform genotyping and haplotyping analysis of the multidrug resistance (ATP-binding cassette, subfamily B, member 1 – ABCB1) gene in FMF patients.2. Three ABCB1 gene polymorphisms (C1236T, G2677T/A and C3435T) were analyzed in 309 FMF patients and 250 healthy control subjects. All subjects were genotyped by PCR–restriction fragment length polymorphism analysis, and statistical analysis was performed using the Arlequin 3.1.1 and SPSS 16.0 software packages.3. The CT genotype frequency of the C3435T polymorphism (p = 0.003), the CT–GT–CT (C1236T–G2677T/A–C3435T) triple genotype (p = 0.001) and the C–G (C1236T–G2677T/A) haplotype (p = 0.030) were more common in the FMF patients. The CT … |
| Anahtar Kelimeler |
