DD genotype of ACE gene I D polymorphism is associated with Behcet disease in a Turkish population
Yazarlar (9)
Serbulent Yigit
Sengul Tural
Aydin Rustemoglu
A Inanir
U Gul
G Kalkan
S Akkanet
N Karakuş
O Ateş
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Mol Biol Rep | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2013 |
| Cilt / Sayı / Sayfa | 40 / 1 / 365–368 | DOI | – |
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Behcet’s disease (BD) is a chronic, multi-systemic and inflammatory disorder. The local renin-angiotensin system (RAS) in the vessel wall plays a role in the endothelial control and contributes to inflammatory processes. Angiotensin-converting enzyme (ACE) is the regulatory component of the RAS. This study was conducted in Turkish patients with BD to determine the frequency of I/D polymorphism genotypes of ACE gene. Genomic DNA obtained from 566 persons (266 patients with BD and 300 healthy controls). ACE gene I/D polymorphism genotypes were determined using polymerase chain reaction using I and D allele-specific primers. There was statistically significant difference between the groups with respect to genotype distribution (p < 0.001). This study is the largest study in Turkish population that ACE gene I/D polymorphism investigated in BD. As a result of this study, ACE gene I/D polymorphism DD … |
| Anahtar Kelimeler |
