Maternal l-thyroxine treatment during lactation affects learning and anxiety-like behaviors but not spatial memory in adult rat progeny
Yazarlar (4)
Burak Tan Erciyes Üniversitesi, Türkiye
Dr. Öğr. Üyesi Umut BAKKALOĞLU Hatay Mustafa Kemal Üniversitesi, Türkiye
Meral Aşçıoğlu
Erciyes University, Faculty Of Medicine, Türkiye
Erciyes University, Faculty Of Medicine, Türkiye
Cem Süer Erciyes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pharmacological Reports (Q2) | ||
| Dergi ISSN | 1734-1140 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 73 / 2 / 454–463 | DOI | 10.1007/s43440-020-00214-y |
| Makale Linki | http://dx.doi.org/10.1007/s43440-020-00214-y | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| BackgroundThe present study compared behavioral and molecular indicators of hippocampal function in l-thyroxine treated rats to determine whether thyroid hormone excessiveness produces relatively stable lifelong changes.MethodsHyperthyroidism was induced in rats by daily injections of l-thyroxine (0.2 mg/kg) to their dams for lactation period (MOH: maternal-onset hyperthyroidism) or to the rats itself during the young adult period (AOH: adult-onset hyperthyroidism; between the day 39–60). Spatial learning was assessed in the Morris Water Maze (MWM). Levels of type 2 and type 3 deiodinases, Erk1/2, JNK and P38MAPK were assessed via western blotting in the hippocampus of trained rats. Measurements were all done in rats aged 60–66 days.ResultsIn MWM, maternally treated rats with l-thyroxine swam more away from the hidden platform, with showing more anxiety-like behavior, as compared to the rats … |
| Anahtar Kelimeler |
| Hippocampus | Lactational hyperthyroidism | Learning and memory | Morris water maze |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |